PECULIARITIES OF SYSTEMIC PATHOBIOCHEMICAL REACTIONS TO BRAIN ISCHEMIA-REPERFUSION IN RATS WITH DIABETES MELLITUS

The objective of the research was to study signs oxidative stress, state proteolysis, and proteinase-inhibiting system blood plasma in rats with streptozotocin-induced diabetes mellitus (60 mg/kg intra-abdominally), complicated by cerebral ischemia-reperfusion. Levels products lipid peroxide oxidation, protein modification, nitrogen oxide metabolites, activity antioxidant protection enzymes were determined means biochemical methods one hour after completion reperfusion period on 12th day. Increased intensity peroxidation found occur without both terms observation. This accompanied an increase all enzymes, while animals amount decreased ground prevailing depression enzymes. Irrespective a tendency changes POM ischemia-reperfusion, their content is reliably higher observation than those diabetes, which indicative oxidation. Without proteolytic reacts increasing values studied parameters against background suppression proteinase inhibitory during entire period, rats, proteolysis remain data obtained allowed us that considerably modifies response systemic pathobiochemical indices